Elder Scrolls 4 Oblivion: Running at 2560x1600 with NVIDIA Enhanced Application mode 16xQ, extremely rare 1‐2 second pauses occur during some fighting. 
This appears to be an application issue in how large textures are created during the in-game fighting.
If I ran it at those settings I'm pretty sure I'd have extremely frequent 1-2 minute pauses, screw an odd second lost here and there.
Reminds me of a similar bug report in the release notes once. It was a very new game at insanely high resolution with max AA and AF applied running on a GeForce4 series card. I can't remember very well but I believe the report mentioned the game crashes to the desktop on launch. If it didn't you'd wish it had done...